Ribociclib / LEE011 / CAS 1256963-02-6

Ribociclib / LEE011 / CAS 1256963-02-6

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Ribociclib Basic information
Product Name: Ribociclib
Synonyms: LEE011;CDK4/6 inhibitor;CDK4 inhibitor;CDK4-IN-1;CS-842;4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(dimethylamino)piperidin-1-yl)pyridin-2-yl)pyrimidin-2-amine;CDK 4/6 Inhibitor, >=98%
CAS: 1256963-02-6
MF: C22H29ClN8
MW: 440.97
Product Categories: Small molecule inhibitor; Pharmaceutical raw materials; Small molecule inhibitors, natural products; Cell biological reagents; Active pharmaceutical ingredients. Inhibitors
Application Ribociclib is an inhibitor of cyclin-dependentkinases4/6 (CDK4/6). These kinases bind to cellular D-cyclin proteins to form active complexes, It plays a key role in the signaling pathways regulating cell cycle progression and cell proliferation.

Ribociclib is indicated for use in combination with an aromatase inhibitor as initial endocrine therapy in postmenopausal women with HR + positive, HER2 advanced or metastatic breast cancer.

Ribociclib Chemical Properties
Melting point >180°C (dec.)
Boiling point 679.3±65.0 °C(Predicted)
Density 1.31±0.1 g/cm3(Predicted)
pKa 7.57±0.50(Predicted)
Storage condition -20°C Freezer
Solubility DMSO (Slightly), Methanol (Slightly)
form Powder.
color White

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