| Agomelatine Basic information | |
| Product Name: | Agomelatine |
| Synonyms: | Melitor;VALDOXAN; MELITOR; THYMANAX;CS-1963;AgoMelatine(S-20098,Valdoxan);S20098,N-[2-(7-Methoxynaphth-1-yl)ethyl]acetamide;S 20098;AGOMELATIN;Acetamide, N-(2-(7-methoxy-1-naphthalenyl)ethyl)- |
| CAS: | 138112-76-2 |
| MF: | C15H17NO2 |
| MW: | 243.3 |
| EINECS: | 629-727-7 |
| Product Categories: | Antidepressants; Psychotropic drugs; Small molecule inhibitors; Proteins and derivatives; Signal transduction pathway kinase inhibitors; Active pharmaceutical ingredients & gt; Neurological medication & GT; Antidepressant, manic drugs & GT; Agomelatine; Characteristic raw materials; AromaticsCompounds; Aromatics; Neurochemicals; APIS; API; Agomelatine; Valdoxan,Melitor,Thymanax; |
| Mol File: | 138112-76-2.mol |
| Introduction | Agomelatine is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression. |
| Application | Agomelatine is a melatoninergic agonist and selective antagonist of 5-HT2C receptors, and has been shown to be active in several animal models of depression. Agomelatine (S20098) displayed pKi values of 6.4 and 6.2 at native (porcine) and cloned, human (h)5-hydroxytryptamine (5-HT)2C receptors, respectively. |
| Agomelatine Chemical Properties | |
| Melting point | 107-109°C |
| Boiling point | 478.8±28.0 °C(Predicted) |
| density | 1.109±0.06 g/cm3(Predicted) |
| pKa | 16.17±0.46(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: >50mg/mL |
| form | Powder |
| color | white to off-white |
| Merck | 14,190 |
| InChIKey | YJYPHIXNFHFHND-UHFFFAOYSA-N |
